fig2

Figure 2. LPS upregulates additional pro-inflammatory genes in sAH. (A) UpSet plot summarizing the LPS responsive genes in NK cells and 2 clusters of effector CD8 T cells from sAH and HC. Bars indicate the number of genes upregulated in response to LPS. Black dots indicate intersections of the data, or in other words, genes upregulated in multiple cell types. Red boxes are genes upregulated only in sAH cytotoxic cells. Blue boxes are genes upregulated in sAH and HC cytotoxic cells. (B and C) Correlation analysis to see how genes in NK cells are coordinately expressed in response to LPS for healthy control (B) and sAH (C). Blue squares indicate genes with highly correlated expression, while red squares indicate anti-correlated expression. Cytolytic granule genes are in bold. sAH: Severe alcohol-associated hepatitis; HC: healthy controls.