Cover Picture: The liver secretes an ample number of hepatokines. Several of them show a positive correlation with IR, are increased in NAFLD, and are directly implicated in the liver-muscle crosstalk. This group comprises angiopoietin-like proteins, fetuin-A, follistatin, hepassocin, leukocyte cell-derived chemotaxin 2 (LECT2), and selenoprotein P.
Cortisol can be a potential biomarker in sarcopenia and NAFLD. As cortisol activity at cellular level is controlled by 11β-hydroxysteroid dehydrogenase type 1 and 2 (11β-HSD1/2) enzymes that convert inactive steroid precursor into active cortisol, these enzymes can be targeted for the study of sarcopenia and NAFLD. Combined studies on NAFLD and sarcopenia with respect to cortisol open a new avenue of research in the understanding of both disorders.
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